Add 10 ml of diluent see compatibility and stability. The dosage of imipenem and cilastatin for injection i. Injection vial 500mg imipenem and 500mg cilastatin powder add 10ml of compatible iv fluid to the powder in each 500mg vial and shake to form a suspension which must be further diluted before iv infusion. Iv ozone, high dose vitamin c booklet index page no. Add 2 ml or 3 ml of 1% lidocaine hcl solution without epinephrine. Primaxin is not recommended in pediatric patients with cns infections because of the risk of seizures see dosage and administration 2. For adult patients with normal renal function creatinine clearance of greater than or equal to 90 mlmin, the recommended dosage regimens are. Compatibility depends upon many factors including temperature, ph, iv fluid, concentration, order of mixing and brand of drug. Device indications for use contraindications midline catheters indicated for short or long term peripheral access to. The bactericidal activity of imipenem results from the inhibition of cell wall synthesis. Primaxin synonyms, primaxin pronunciation, primaxin translation, english dictionary definition of primaxin.
It is made from a combination of imipenem and cilastatin. Primaxin iv 500mg500mg powder for solution for infusion imipenem cilastatin. Intravenous compatibility chart drug information for the. It does say that cefipime and vanco are ysite incompatible but does not specify if they are safe from different iv sights, for this reason i wouldnt do it. These highlights do not include all the information needed. Read all of this leaflet carefully before you start using this medicine because it contains important information for you. There is an antibiotic imipramine something like that its combination with some other antibiotc cant remember the name so the question is can we piggyback that antibiotic with d5w.
Critical care intravenous drug administration guide. Primaxin may be administered concomitantly with other antibacterial drugs, such as aminoglycosides. Home explore intravenous compatibility chart drug information for the. Imipenemcilastatin, sold under the brand name primaxin among others, is an antibiotic useful for the treatment of a number of bacterial infections. Running multiple iv antibiotics at one time general. Primaxin iv will be prepared and given to you by a doctor or another health care professional. Primaxin iv 500 mg500 mg powder for solution for infusion. This medicine will not work for colds, flu, or other virus infections imipenem and cilastatin combination is used to treat infections in many different parts of the body. Handbook on injectable drugs, 20th edition ahfs drug. This medication is known as a carbapenemtype antibiotic. Compatibility of imipenemcilastatin sodium with commonly. Each vial contains sodium bicarbonate equivalent to approximately 1.
Primaxin trade name for a parenteral antibiotic antibiotic, antibiotic drug a chemical substance derivable from a mold or bacterium that can. I had a question about compatibility of iv antibiotics. Intravenous compatibility chart free html5 flip book. The recipient will receive more details and instructions to access this offer. Iv antihypertensives, analgesicslxxx 403 polycythemia 7. Ive consulted the drug book and found that no contraindications exist for giving vanco and flagyl at once.
Imipenemcilastatin by injection national library of. Primaxin is not indicated in patients with meningitis because safety and efficacy have not been established. Primaxin iv fda prescribing information, side effects. Each 500mg of dose should be diluted with 100ml of compatible iv fluid, whilst for a. Transfer the reconstituted suspension in iv bagbottle. The recommended dose for adults and adolescents is 500 mg500 mg every 6 hours or 1,000 mg1,000 mg every 6 or 8 hours. Imipenem with cilastin iv wellington icu drug book. Primaxin iv 500mg500mg powder for solution for infusion. This medication is used to treat a wide variety of bacterial infections.
See full prescribing information for dosage recommendations in. Primaxin is a combination of imipenem and cilastatin. See instructions for use of primaxin in addvantage vials for reconstitution and preparation. Your doctor will decide how much primaxin iv you need. Detailed listing of the iv drug compatibility and stability updates applied to the king guide to parenteral admixtures over the last 12 years. Add 10ml of compatible iv fluid to the powder in each 500mg vial and shake to form a suspension which must be further diluted before iv infusion. Each vial contains imipenem monohydrate equivalent to 500 mg imipenem anhydrate and cilastatin sodium equivalent to 500 mg cilastatin. It works by killing bacteria or preventing their growth.
Preventive strategies always check for compatibility standardize protocol for drug preparation check for alternative modes of administration separation of drug doses by time and place usage of multilumen catheters use inline filters 18. Primaxin iv 500 mg500 mg powder for solution for infusion emc. Incompatibility and compatibility of primaxin with other antibacterial drugs do not mix primaxin with, or physically add to, other antibacterial drugs. Specifically it is used for pneumonia, sepsis, endocarditis, joint infections, intraabdominal infections, and urinary tract infections. Compatibility and stability of drug products and preparations. Dailymed primaxin iv imipenem and cilastatin sodium. Normal saline 5% dextrose store at room temperature for infusion dilute with compatible iv fluid to a. Primaxin imipenemcilastatin dosing, indications, interactions. An equivalent amount of cilastatin is also present in the solution. Each 125 mg, 250 mg, or 500 mg dose should be given by intravenous administration over 20 to 30 minutes. Chapter 37 compatibility and stability of drug products and preparations 683 lwbk127c37671701. Check tubing below ysite carefully for discoloration, cloudiness or precipitation blank do not mix. Imipenem and cilastatin combination is used in the treatment of infections caused by bacteria. Imipenem and cilastatin for injection is a sterile formulation of imipenem a thienamycin antibiotic and cilastatin sodium the inhibitor of the renal dipeptidase, dehydropeptidase l, with sodium bicarbonate added as a buffer.
The dosage of primaxin in adult patients should be based on suspected or confirmed pathogen susceptibility. This iv drug compatibility chart is provided as a quick reference, however since information is subject to change it is advised that you check with a pharmacist for recommendations as well as product information to check for any changes or additional incompatibilities. Medscape indicationspecific dosing for primaxin imipenemcilastatin. Imipenem and cilastatin is a combination medicine used to treat severe infections of the heart, lungs, bladder, kidneys, skin, blood, bones, joints, stomach, or female reproductive organs. Iv therapy this booklet is part of the 30 hour administration of intravenous therapy course designed for florida nurses. Its greatest affinity is for penicillin binding proteins pbps 1a, 1b, 2, 4, 5 and 6 of escherichia coli, and 1a, 1b, 2, 4 and 5 of pseudomonas aeruginosa. Primaxin for intravenous use is a combination of imipenem, a penem. Compatibility of imipenem cilastatin sodium with commonly used intravenous solutions. Primaxin for intravenous use is indicated for the treatment of lower respiratory tract infections caused by susceptible strains of staphylococcus aureus penicillinaseproducing isolates, acinetobacter species, enterobacter species, escherichia coli, haemophilus influenzae, haemophilus parainfluenzae, klebsiella species, serratia marcescens. Reconstitute infusion bottles with 100 ml of compatible diluent. Agitate to form a suspension, then withdraw and inject the entire contents of vial intramuscularly. Read all of this leaflet carefully before you start using this medicine because it contains. Primaxin definition of primaxin by the free dictionary.
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